Table 4.
Age- and multivariate-adjusted HRs for the association between psoriasis/psoriatic arthritis and non-fatal CVD
| Cases | Person-years | Age-adjusted HR (95% CI) |
Multivariate-adjusted HR * (95% CI) |
|
|---|---|---|---|---|
| Non-fatal CVD | ||||
| No psoriasis | 688 | 1,677,052 | 1.00 | 1.00 |
| Only Psoriasis | 15 | 27,804 | 1.27 (0.76-2.11) | 1.13 (0.68-1.89) |
| Psoriatic arthritis/psoriasis | 10 | 4,213 | 5.32 (2.85-9.94) | 3.47 (1.85-6.51) |
| Ptrend | <0.001 | 0.002 | ||
| Non-fatal MI | ||||
| No psoriasis | 344 | 1,677,379 | 1.00 | 1.00 |
| Only Psoriasis | 8 | 27,813 | 1.34 (0.66-2.70) | 1.12 (0.56-2.27) |
| Psoriatic arthritis/psoriasis | 7 | 4,216 | 7.40 (3.50-15.66) | 4.18 (1.96-8.90) |
| Ptrend | <0.001 | 0.003 | ||
| Non-fatal Stroke | ||||
| No psoriasis | 347 | 1,677,377 | 1.00 | 1.00 |
| Only Psoriasis | 8 | 27,811 | 1.35 (0.67-2.73) | 1.27 (0.63-2.56) |
| Psoriatic arthritis/psoriasis | 3 | 4,220 | 3.18 (1.02-9.91) | 2.40 (0.77-7.51) |
| Ptrend | 0.05 | 0.13 |
Simultaneously adjusted for age, body mass index (underweight <18.5, normal weight 18.5-24.9, overweight 25-29.9, and obesity ≥40 kg/m2), smoking status (never, past, current smoking with 1-14, 15-24 or ≥25 cigarettes/day), alcohol intake (no, <5.0, 5.0-9.9 or ≥10.0 g/d), physical activity (<3.0, 3.0-8.9, 9.0-17.9, 18.0-26.9 or ≥27.0 metabolic equivalent hours/wk), race (Caucasian, Asian, Hispanic or African American), family history of stroke/MI (yes or no), hypertension (yes or no), hypercholesterolemia (yes or no), current aspirin use (yes or no), multi-vitamin use (yes or no), postmenopausal hormone use (premenopause, never, current or past users) , oral contraceptives use (never, past or current users).