Table 5.

The association between psoriasis diagnosis age or duration time and risk of incident non-fatal CVD

	Cases	Person-years	Age-adjusted HR (95% CI)	Multivariate-adjusted HR * (95% CI)
Psoriasis diagnosis age
No psoriasis	678	1,677,047	1.00	1.00
Diagnosis age <40 years	4	3,198	3.98 (1.48-10.70)	3.26 (1.21-8.75)
Diagnosis age ≥40 years	5	4,747	2.03 (0.84-4.91)	1.60 (0.66-3.88)
Psoriasis duration time †
No psoriasis	678	1,677,047	1.00	1.00
Psoriasis <9 years	5	5,542	2.02 (0.84-4.89)	1.64 (0.68-3.96)
Psoriasis ≥9 years	4	2,404	4.04 (1.51-10.83)	3.09 (1.15-8.29)

^*Simultaneously adjusted for age, body mass index (underweight <18.5, normal weight 18.5-24.9, overweight 25-29.9, and obesity ≥40 kg/m²), smoking status (never, past, current smoking with 1-14, 15-24 or ≥25 cigarettes/day), alcohol intake (no, <5.0, 5.0-9.9 or ≥10.0 g/d), physical activity (<3.0, 3.0-8.9, 9.0-17.9, 18.0-26.9 or ≥27.0 metabolic equivalent hours/wk), race (Caucasian, Asian, Hispanic or African American), family history of stroke/MI (yes or no), hypertension (yes or no), hypercholesterolemia (yes or no), current aspirin use (yes or no), multi-vitamin use (yes or no), postmenopausal hormone use (premenopause, never, current or past users) , oral contraceptives use (never, past or current users).

^†Psoriasis duration time is defined as the time from diagnosis date of psoriasis to diagnosis date of non-fatal CVD, death, or end of the follow up, whichever comes first.