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. Author manuscript; available in PMC: 2014 Jan 8.
Published in final edited form as: J Periodontol. 2011 Apr 13;82(12):10.1902/jop.2011.110103. doi: 10.1902/jop.2011.110103

Figure 2. Histological analysis of periodontal defect healing in WT and Ank KO.

Figure 2

Representative H&E stained slides from WT and Ank KO mice at 15, and 30 days post-surgery. Arrows indicate margins of pre-existing cementum and rectangles define the instrumented root area used for linear measurements that is also presented in higher magnification. At 15 days post-surgery, both WT and Ank KO roots featured newly formed bone and fibrous tissue. New cementum, predominantly of the cellular type, was observed more frequently in Ank KO mice. By day 30, restoration of overlying alveolar bone was observed in defects in both WT and Ank KO mice. In Ank KO at this time point, new cementum formation was present more consistently on all cut root surfaces, compared to WT controls - Original magnification: figures A, B, E and F: 200x and figures C, D, G and H: 400x. Abbreviations: B: bone; D: dentin, C: cementum, star: periodontal ligament.