. Author manuscript; available in PMC: 2014 Nov 13.

Published in final edited form as: J Am Chem Soc. 2013 Nov 5;135(45):10.1021/ja4079754. doi: 10.1021/ja4079754

Table 3.

Thermal melting temperatures of modified siRNAs

		Guide position 12 modification
	unmodified	1-ER	1-ER triazole I	1-ER triazole II

siRNA T_M, °C	64.7 ± 0.4	56.1 ± 0.1	57.0 ± 0.1	56.2 ± 0.3