. Author manuscript; available in PMC: 2014 Jan 8.

Published in final edited form as: Adv Exp Med Biol. 2013;961:10.1007/978-1-4614-4756-6_1. doi: 10.1007/978-1-4614-4756-6_1

Table 2.

Expression of Na/Ca exchanger-1 (NCX1) and some TRPC protein components of receptor-operated channels (ROCs) is increased in several hypertensive animal models and in human primary pulmonary hypertension. Modified from Blaustein et al, 2011).

	Hypertension	Artery Smooth Muscle			Reference
		NCX1	ROC
		NCX1	TRPC3	TRPC6
1	Ouabain^* (vs vehicle & digoxin)	↑		↑	(Pulina et al., 2010b; Zulian et al., 2010b)
2	DOCA-salt^*	ND^**		↑	(Bae et al., 2007)
3	Milan hypertension^* (vs Milan NT)^**	↑		↑	(Zulian et al., 2010a)
4	SHR (vs WKY)^**	↑	↑		(Taniguchi et al., 2004; Liu et al., 2009)
5	Dahl salt-sensitive/high (vs low) salt^*	↑		↑	VA Golovina (unpublished)
6	NCX1^SM.Tg/Tg ^**	↑		↑	(Iwamoto et al., 2004); J Zhang & MP Blaustein (unpublished)
7	Angiotensin II	↑		ND^**	L Chen, M Li & MP Blaustein (unpublished)
8	Human primary pulmonary hypertension	↑	↑	↑	(Yu et al., 2004; Zhang et al., 2007a; Zhang et al., 2007b)

Hypertension associated with elevated plasma ouabain levels.

^**

Not determined.

^**

Abbreviations: NT, normotensive control; SHR, spontaneously hypertensive rat; WKY, Wistar-Kyoto normotensive control for SHR; NCX1^SMTg/Tg, smooth muscle-specific NCX1 knockout mouse (Zhang et al., 2010).