Table 3. Preliminary PK/PD Assessment for Compounds Dosed Orally at 20 mg/kg for up to 10 Days to Mice Infected with T. cruzi^a.

compd	IC50 (μM)	plasma concn, 0.5 h (μM)	plasma concn, 24 h (μM)	parasites cleared from blood during 10-day dosing?
47	0.024	3.31	0.016	no
48	0.013	1.29	0.008	no
49	0.061	3.26	0.001	no
4	0.019	2.42	0.002	no
50	0.047	5.29	0.002	no
51	0.058	3.28	0.001	no
5	0.011	0.85	0.490	yes
2	0.012	2.49	0.030	yes
52	0.002	1.37	0.047	yes
6	0.017	5.54	0.790	yes
(rac)-7	0.007	1.55	0.370	yes
posaconazole	0.001	3.04	2.89	yes

^aPlasma exposure data were obtained in a parallel group of noninfected mice following a single oral dose of 20 mg/kg.