Table 5. Pharmacokinetic Parameters in Mice after Intravenous and Oral Administration of 6 and (S)-7.

parameter	6	(S)-7
iv dose (mg/kg)	2	2
po dose (mg/kg)	20	20
plasma CL (mL min–1 kg–1)	8.1	7.7
plasma Vss (L/kg)	4.4	4.2
half-life, iv/po (h)	8.6/12.5	5.9/8.2
oral bioavailability (%)	95	64