TABLE 2. Sensitivity of Molecular Breast Imaging as a Function of Tumor Size and Detector Heads Viewed During Blinded Review by Three Readers.
Tumor Diameter (mm) |
No. of Tumors |
Detector Head(s) Used |
Reader 1 |
Reader 2 |
Reader 3 |
Average Sensitivity (%) |
p | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Tumors |
Sensitivity (%) |
No. of Tumors |
Sensitivity (%) |
No. of Tumors |
Sensitivity (%) |
||||||||
TP | FN | TP | FN | TP | FN | ||||||||
| |||||||||||||
0–5 | 16 | Single | 7 | 9 | 44 | 7 | 9 | 44 | 7 | 9 | 44 | 44 | 0.130 |
Dual | 11 | 5 | 69 | 11 | 5 | 69 | 10 | 6 | 63 | 67 | |||
6–10 | 45 | Single | 31 | 14 | 69 | 39 | 6 | 87 | 33 | 12 | 73 | 76 | 0.060 |
Dual | 41 | 4 | 91 | 41 | 4 | 91 | 36 | 9 | 80 | 87 | |||
11–15 | 30 | Single | 28 | 2 | 93 | 29 | 1 | 97 | 28 | 2 | 93 | 94 | 1.00 |
Dual | 29 | 1 | 97 | 29 | 1 | 97 | 29 | 1 | 97 | 97 | |||
16–20 | 19 | Single | 16 | 3 | 84 | 16 | 3 | 84 | 16 | 3 | 84 | 84 | 0.50 |
Dual | 18 | 1 | 95 | 18 | 1 | 95 | 18 | 1 | 95 | 95 | |||
> 20 | 18 | Single | 16 | 2 | 89 | 17 | 1 | 94 | 17 | 1 | 94 | 92 | 1.00 |
Dual | 18 | 0 | 100 | 18 | 0 | 100 | 18 | 0 | 100 | 100 | |||
All tumors ≤ 10 | 61 | Single | 38 | 23 | 62 | 46 | 15 | 75 | 40 | 21 | 66 | 68 | 0.004 |
Dual | 52 | 9 | 85 | 52 | 9 | 85 | 46 | 15 | 75 | 82 | |||
| |||||||||||||
All tumors | 128 | Single | 98 | 30 | 77 | 108 | 20 | 84 | 101 | 27 | 79 | 80 | < 0.0005 |
Dual | 117 | 11 | 91 | 117 | 11 | 91 | 111 | 17 | 87 | 90 |
Note—Difference in the average sensitivity of dual-head molecular breast imaging compared with single-head molecular breast imaging was statistically significant using the McNemar test. Boldface indicates statistical significance. TP = true-positive, FN = false-negative.