Figure 1.

CAD model of the six-chamber bioreactor (a). CAD model of the single culture chamber: exploded and assembled view; the culture chamber is composed by a reservoir, a disposable screw cap, a housing, and a scaffold holder cartridge (b). Detail of a scaffold holder cartridge with a 10 mm opening diameter; the arrows indicate the upper and lower gaskets; the cartridge allows hosting matrices with different sizes and shapes (c). Sketch of the fluidic circuit with parallel culture chambers and perfusion circuits, actuated by a multichannel peristaltic pump (three out of six parallel circuits/chambers are shown) (d).