Figure 1. Synaptic staining pattern of γ-aminobutyric acid-B receptor–immunoglobulin G compared with NMDA-R-IgG staining pattern (tissue immunofluorescence).

The γ-aminobutyric acid-B receptor (GABA_BR)–immunoglobulin G (IgG) binding in the cerebrum (A) is most prominent in the thalamus (t), and is also seen in hippocampus (h), cerebral cortex (cx), and striatum (s). GABA_BR-IgG also binds to cerebellum (B, both molecular [m] and granular [g] layers), midbrain (mb, panel C), and myenteric neurons (arrowheads). In contrast, NMDA-R-IgG binding is most prominent in the hippocampus (h, panel D) and cerebellar granular layer (g, panel E); myenteric neurons are not stained (not shown).