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How changes in pH affect folate influx kinetics parameters mediated by the proton-coupled folate transporter (PCFT). (Top panel) The pattern of changes in influx Km is compared among folic acid, methotrexate (MTX), and pemetrexed. (Bottom panel) The pattern of changes in influx Vmax for folic acid and pemetrexed. From References 97 and 158.
