Table 2.

Mean (SD) Values and t-Test Statistics of Baseline Nondisplaceable Binding Potential and Task-Induced Stress, Psychotic Experiences, and [¹⁸F]fallypride Ligand Displacement for Control Subjects and First-Degree Relatives

	Control Subjects (n = 10)	First-Degree Relatives (n = 14)	ta	P-Values
Nondisplaceable binding potential (BPND)
vmPFC (left)	0.19 (0.24)	0.15 (0.20)	0.51	.616
vmPFC (right)	0.22 (0.22)	0.18 (0.22)	0.39	.698
ΔSubjective stressb	0.98 (0.68)	1.31 (0.74)	−1.13	.270
ΔSubjective psychosisc	0.09 (0.22)	0.03 (0.30)	0.53	.601
[18F]fallypride ligand displacement (%)d
vmPFC(left)	54.1 (24.0)	41.6 (27.0)	1.16	.258
vmPFC (right)	48.7 (22.0)	38.1 (28.2)	0.99	.333

^a t-value (comparing group means; 2-sided P-value presented).

^bDifference between mean scores on the subjective stress scale under stress vs control conditions of the MIST psychosocial stress task.

^cDifference between mean scores on the psychosis scale under stress vs control conditions of the MIST psychosocial stress task.

^dPercentage of voxels exceeding the FDR corrected significance threshold of P(α(FDR) = 5%) < 0.05, reflecting spatial extent of task-induced ligand displacement. Percentages reflect the number of significant voxels relative to the total number of voxels within the mask of the respective brain region.