Fig. 3.

Top 42 schizophrenia candidate genes identified by convergent functional genomics (CFG) encode a significantly interconnected protein-protein interaction (PPI) network. (A) PPI network constructed with top schizophrenia genes that were identified using translational CFG of schizophrenia. (B) The direct connectivity network is statistically highly significant (has more edges) compared with 10 000 random networks (P = .000099, corrected), suggesting top schizophrenia susceptibility genes are preferential toward physical interaction. KEGG pathways that were significantly overrepresented among genes forming the direct network are shown in the red box. P values were corrected by the Benjamini-Hochberg procedure in DAVID.