Table 1.
Gene Set Enrichment Analysis of Genes Defined by 81 Top Single-Nucleotide Polymorphisms (SNPs) From the Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC)
| Category | Database ID | Term | Padj |
|---|---|---|---|
| GOTERM_BP_FAT | GO:0006334 | Nucleosome assembly | 5.72E-15 |
| GOTERM_BP_FAT | GO:0019882 | Antigen processing and presentation | 1.08E-10 |
| GOTERM_BP_FAT | GO:0006986 | Response to unfolded protein | 4.32E-08 |
| GOTERM_BP_FAT | GO:0002474 | Antigen processing and presentation of peptide antigen via MHC class I | 2.23E-07 |
| GOTERM_BP_FAT | GO:0048002 | Antigen processing and presentation of peptide antigen | 3.93E-07 |
| GOTERM_BP_FAT | GO:0051789 | Response to protein stimulus | 3.64E-07 |
| GOTERM_BP_FAT | GO:0006952 | Defense response | 4.46E-05 |
| GOTERM_BP_FAT | GO:0002504 | Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 4.40E-04 |
| GOTERM_BP_FAT | GO:0006955 | Immune response | 9.77E-04 |
| GOTERM_BP_FAT | GO:0007584 | Response to nutrient | .0111 |
| GOTERM_BP_FAT | GO:0048660 | Regulation of smooth muscle cell proliferation | .0290 |
| GOTERM_BP_FAT | GO:0031667 | Response to nutrient levels | .0297 |
Note: MHC, major histocompatibility complex. The table shows GO terms identified by DAVID that are enriched among 256 genes defined by 81 top SNPs from Schizophrenia PGC. P adj values in the table represent P values adjusted by the Benjamini-Hochberg procedure in DAVID. The terms in bold matched the GO terms from the analysis of 548 genes with significantly altered expression levels in dorsolateral prefrontal cortex (DLPFC) of schizophrenia patients.