. Author manuscript; available in PMC: 2014 Jun 12.

Published in final edited form as: Breast Cancer Res Treat. 2013 Jun 12;139(3):10.1007/s10549-013-2581-3. doi: 10.1007/s10549-013-2581-3

Table 5.

Multivariate analysis for the effect of clinicopathologic parameters and PD1 expression on overall survival

Clinicopathologic parameter	Hazard ratio (95 % CI)	p value
Age (per 1-year)	1.038 (1.027–1050)	< 0.0001
Tumor stage
pT1 (reference)	1
pT2	1.559 (1.036–2.347)	0.0334
pT3	2.157 (1.120–4.154)	0.0216
pT4	2.588 (1.572–4.261)	0.0002
Lymph node involvement
pN1 (reference)	1
pN1	1.310 (0.955–1.798)	0.0940
pN2	2.315 (1.499–3.576)	0.0002
Tumor grade
BRE grade 1 (reference)	1
2	1.751 (1.119–2.740)	0.0142
3	2.435 (1.535–3.863)	0.0002
Intrinsic subtypes
Luminal A	1
Luminal B (HER2⁻)	1.558 (0.877–2.770)	0.1306
Luminal B (HER2⁺)	1.838 (0.951–3.551)	0.0702
Basal-like	2.761 (1.482–5.143)	0.0014
PD-1 expression, all cases
PD-1⁺	1.532 (1.070–2.194)	0.0198