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. Author manuscript; available in PMC: 2014 Jan 8.
Published in final edited form as: J Rheumatol. 2013 May 15;40(7):10.3899/jrheum.121131. doi: 10.3899/jrheum.121131

Figure 4.

Figure 4

A. Gene expression profiles from pretreatment sJIA PBMC. RNA was collected from PBMC and assayed for differentially expressed genes based on FSTL-1 serum level above or below 200 ng/ml. Gene clusters are represented on the left with approximate locations of genes. B. Schema for utility of FSTL-1 and ferritin/ESR ratio as biomarkers in sJIA. FSTL-1 and ferritin are useful as markers of patients with altered gene expression suggestive of MAS, and of active MAS. Ferritin/ESR ratio can discriminate between active MAS and subclinical MAS or sJIA alone. PBMC: peripheral blood mononuclear cells; sJIA: systemic juvenile idiopathic arthritis; FSTL-1: Follistatin-like protein 1; ESR: erythrocyte sedimentation rate; MAS: macrophage activation syndrome; CRP: C-reactive protein.