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. 2013 Dec 23;4(1):21–28. doi: 10.5681/apb.2014.004

Figure 7 .

Figure 7

Histopathological evaluation of mice liver treated with methimazole (100 mg/kg). The effect of glutathione reservoirs depletion on methimazole-induced hepatotoxicity. Hematoxylin and eosin (H&E) staining. A: Control, B: BSO (1g/kg) control, C: Methimazole (100 mg/kg), D: Methimazole (100 mg/kg) + BSO (1g/kg), E: Methimazole (100 mg/kg) + NAC (300 mg/kg), F: Methimazole (100mg/kg) + BSO (1g/kg) + NAC (300 mg/kg). Methimazole caused a mild Inflammatory cell infiltration (C). A severe inflammatory cells infiltration, and widespread bridging necrosis of liver (D) was occurred when glutathione-depleted animals were treated with methimazole. NAC (300 mg/kg) administration, alleviated methimazole-induced changes in normal (E) and/or glutathione-depleted (F) animals.