Skip to main content
. 2013 Dec 23;4(1):21–28. doi: 10.5681/apb.2014.004

Figure 8.

Figure 8

Effect of enzyme-induction on mice liver histopathological changes, caused by methimazole (100 mg/kg). A: normal control, B: Methimazole (100 mg/kg), C:BNF-induced + Methimazole (100 mg/kg), D: Phenobarbital-induced + Methimazole (100 mg/kg), E: BNFinduced + Methimazole (100 mg/kg) + NAC (300 mg/kg), F: Phenobarbital-induced + Methimazole (100 mg/kg) + NAC (300 mg/kg). When enzyme-induced animals were treated with methimazolea severe and widespreadnecrosis of liver parenchymal cells and inflammatory cells infiltration was occurred (C & D), mitigation of methimazole-induced changes in enzyme-induced animals was observed by NAC (300 mg/kg) administration, which reduced necrosis and inflammatory cells infiltration (E&F).