Table 1. Clinical characteristics and biochemistry data of patients by gender-specific tertiles of UA.

Variables	Tertile 1M: 2.09∼5.79 mg/dL FM: 1.74∼5.37 mg/dL	Tertile 2M: 5.80∼7.38 mg/dL FM: 5.38∼6.65 mg/dL	Tertile 3M: 7.39∼16.7 mg/dL FM: 6.66∼8.08 mg/dL	P values&
N	731	731	731	—
Age, yrs	61.9±15.1***	57.7±15.4ΔΔΔ	54.7±15.3###	<0.001
Male (%)	49.2	49	49.2	0.99
BMI, Kg/m2	22.4±3.5***	23.3±3.6	23.1±3.7###	<0.001
Diabetes (%)	40.2	40.6ΔΔ	32.8##	0.003
CVD history (%)	34.8**	42.7	46.6###	<0.001
Systolic blood pressure, mmHg	133.5±22.5**	137.8±18.9	138.7±16.5###	<0.001
Diastolic blood pressure, mmHg	78.4±12.9**	80.5±12.9	82.1±11.2##	<0.001
Triglycerides, mmol/L	1.84±1.28	1.94±1.29	1.87±1.08	0.23
Total cholesterol, mmol/L	4.92±1.27	4.97±1.28	4.82±1.23	0.08
HDL cholesterol, mmol/L	1.16±0.38	1.13±0.35	1.14±0.37	0.2
LDL cholesterol, mmol/L	2.71±0.89	2.71±0.96	2.69±0.93	0.97
Albumin, g/L	33.9±5.4***	35.6±5.1ΔΔ	36.5±5.2###	<0.001
Hemoglogin, g/dL	103.6±19.5	104.2±18.6	101.7±19.8	0.04
UA, mg/dL	4.5±0.8***	6.3±0.5ΔΔΔ	8.4±1.4###	<0.001
Urea nitrogen, mmol/L	17.7±6.3***	21.0±6.3ΔΔΔ	23.1±7.1###	<0.001
Creatinine, umol/L	621.8±242.8***	695.0±246.9ΔΔΔ	728.9±274.5###	<0.001
Corrected calcium, mmol/L	2.29±0.25	2.29±0.25ΔΔΔ	2.25±0.24###	<0.001
Parathyroid hormone, pg/ml	157.8 (74.5, 318.9)	163.5(75.9, 314.8)Δ	196.8(91.8, 345.7)#	0.02
Phosphate, mmol/L	1.4±0.4***	1.6±0.4ΔΔΔ	1.7±0.5###	<0.001
CRP, mg/L	3.1(1.2, 6.9)	2.6(1.0, 7.8)	2.8(1.0, 7.5)	0.32
Total Kt/V	2.19±0.65***	2.01±0.60	1.95±0.63###	<0.001
Total Ccr, L/w/1.73m2	76.2±30.9	73.5±33.6	73.3±30.3	0.23
RRF, ml/min	3.1(1.4, 5.2)	3.2(1.6, 5.2)	3.7(1.8, 5.8)	0.16

Abbreviations: M, male; FM, female; UA, uric acid; BMI, body mass index; CVD, cardiovascular disease; CRP, C-reactive protein; Ccr, creatinie clearance; RRF, residual renal function.

^& P for comparisons among tertiles.

*P<0.05,

P<0.01,

P<0.001 for Tertile 1 vs Tertile 2.

P<0.05,

P<0.01,

P<0.001 for Tertile 2 vs Tertile 3.

^# P<0.05,

^## P<0.01,

^### P<0.01 for Tertile 1 vs Tertile 3.