Skip to main content
. Author manuscript; available in PMC: 2014 Jul 6.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2013 Oct 16;54:10.1146/annurev-pharmtox-011613-135923. doi: 10.1146/annurev-pharmtox-011613-135923

Figure 1. The canonical mammalian circadian oscillator and output relevant for xenobiotic metabolism.

Figure 1

Two interlocked feedback loops composed of activators (green) and repressors (red) that drive gene expression of output genes such as those important for xenobiotic metabolism. Components of these loops make extensive use of auxiliary factors including histone methyltransferases (HMTs), histone deacetylases (HDACs), DHBS family RNA-binding proteins (beige), and kinases and proteasome machinery (grey). Important output genes, involved in transcriptional control of the detoxification metabolism (blue). See text for details.