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. Author manuscript; available in PMC: 2014 Jul 6.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2013 Oct 16;54:10.1146/annurev-pharmtox-011613-135923. doi: 10.1146/annurev-pharmtox-011613-135923

Figure 3. Time of day dependent variation in pharmacokinetics.

Figure 3

Average 3-hourly steady state serum concentrations of theophylline from eight asthmatic children dosed with Theo24© before breakfast (06:00, red) or at bedtime (21:00, blue) as indicated by arrows. Shaded area represents the occurrence of dyspnea. (Adapted from Smolensky et al 1987 and Dethlefsen & Repges (1985) c.f. Smolensky et al. (1987))