Table 4. Comparisons of bile acid profiles in fetal serum.
| Median (IQR) (µmol/L) | Control vs Untreated | Untreated vs. UDCA Treated | Controls vs UDCA Treated | |||
| Control | Untreated | Treated | P value | P value | P value | |
| Total bile acid | 2.80 (1.73–4.62) | 4.94 (3.56–7.57) | 4.34 (2.44–6.50) | 0.0093 ** | 0.3001 | 0.0580 |
| Total CA | 1.00 (0.46–1.99) | 3.47 (1.47–4.18) | 0.91 (0.49–2.06) | 0.0011 ** | 0.0002 *** | 0.9165 |
| CA | 0.00 (0.00–0.07) | 0.07 (0.04–0.14) | 0.05 (0.03–0.07) | 0.0008 ** | 0.0171 * | 0.0039 ** |
| TCA | 0.65 (0.29–1.55) | 1.29 (0.55–1.53) | 0.34 (0.21–0.64) | 0.0829 | <0.0001 *** | 0.0481 * |
| GCA | 0.34 (0.16–0.54) | 1.97 (1.03–2.56) | 0.54 (0.30–1.26) | <0.0001 *** | 0.0011 ** | 0.0413 * |
| Total CDCA | 1.76 (1.20–2.12) | 1.91 (1.10–2.70) | 1.53 (0.92–2.77) | 0.7549 | 0.7809 | 0.8782 |
| CDCA | 0.00 (0.00–0.00) | 0.00 (0.00–0.02) | 0.02 (0.00–0.03) | 0.0603 | 0.0334 * | 0.0018 ** |
| TCDCA | 0.98 (0.75–1.52) | 0.65 (0.35–1.22) | 0.62 (0.38–1.20) | 0.1551 | 0.8185 | 0.0490 * |
| GCDCA | 0.54 (0.41–0.96) | 1.01 (0.48–1.57) | 0.83 (0.42–1.58) | 0.0770 | 0.7543 | 0.1728 |
| Total DCA | 0.01 (0.00–0.03) | 0.02 (0.00–0.04) | 0.00 (0.00–0.03) | 0.3299 | 0.0829 | 0.6719 |
| DCA | 0.00 (0.00–0.02) | 0.01 (0.00–0.02) | 0.00 (0.00–0.03) | - | - | - |
| TDCA | 0.00 (0.00–0.01) | 0.00 (0.00–0.01) | 0.00 (0.00–0.00) | - | - | - |
| GDCA | 0.00 (0.00–0.01) | 0.00 (0.00–0.01) | 0.00 (0.00–0.00) | - | - | - |
| Total LCA | 0.02 (0.02–0.05) | 0.02 (0.01–0.02) | 0.02 (0.01–0.03) | 0.0500 * | 0.8674 | 0.0720 |
| LCA | 0.00 (0.00–0.02) | 0.00 (0.00–0.01) | 0.00 (0.00–0.01) | - | - | - |
| TLCA | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | - | - | - |
| GLCA | 0.02 (0.01–0.02) | 0.02 (0.01–0.02) | 0.01 (0.00–0.02) | 0.3486 | 0.8891 | 0.1293 |
| Total UDCA | 0.01 (0.01–0.03) | 0.03 (0.00–0.44) | 1.37 (0.60–2.60) | 0.3061 | <0.0001 *** | <0.0001 *** |
| UDCA | 0.00 (0.00–0.00) | 0.00 (0.00–0.03) | 0.45 (0.19–0.90) | 0.3734 | <0.0001 *** | <0.0001 *** |
| TUDCA | 0.00 (0.00–0.00) | 0.00 (0.00–0.04) | 0.06 (0.03–0.13) | 0.1560 | 0.0004 *** | <0.0001 *** |
| GUDCA | 0.01 (0.01–0.02) | 0.03 (0.00–0.31) | 0.60 (0.36–1.55) | 0.2821 | <0.0001 *** | <0.0001 *** |
| HyoDCA | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | - | - | - |
| HyoCA | 0.00 (0.00–0.01) | 0.03 (0.02–0.06) | 0.06 (0.04–0.08) | 0.0028 ** | 0.0027 ** | <0.0001 *** |
| άMCA | 0.00 (0.00–0.00) | 0.04 (0.00–0.21) | 0.97 (0.73–1.21) | - | <0.0001 *** | - |
| βMCA | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | 0.00 (0.00–0.00) | - | - | - |
See Table 1 for abbreviatons.