Table 2. Schedule of immunization, blood sampling and parasite challenge of Aotus lemurinus griseimembra.
Day (week) | Immunization | Blood sampling | Challenge* |
0 (1) | X | X | |
14 (2) | X | ||
28 (4) | X | X | |
46 (6) | X | ||
69 (10) | X | X | |
81§ (12) | X | ||
97 (14) | X | X ¶ | |
120 (17) | X |
The day of sampling and/or immunization is shown with the appropriate week of each time point shown in brackets.
i.v. injection (1 x 105 P. falciparum FVO parasites - ring stage).
Parasite challenge Go/No Go decision point, based on IFA titer.
Drug treatment criteria: Parasitemia ≥5% and/or haematocrit ≤20%.