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. 2014 Jan 8;9(1):e83664. doi: 10.1371/journal.pone.0083664

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© 2014 Apri et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Initially, the admissible region of the system is . In this situation, a reduced model can be obtained either by setting or . When a new dataset from a new experiment is incorporated, the admissible region shrinks to . Thus, . Now, a reduced model can only be obtained when .

Inline graphic — Initially, the admissible region of the system is . In this situation, a reduced model can be obtained either by setting or . When a new dataset from a new experiment is incorporated, the admissible region shrinks to . Thus, . Now, a reduced model can only be obtained when .