Table 1. Characteristics of acute stroke patients (n = 81,143) according to preadmission antipsychotic medication use.
| Characteristics | Current antipsychotics users (n = 2,770, 3.41%) | Former antipsychotics users (n = 6,121, 7.54%) | Never antipsychotics users (n = 72,252, 89.0%) | |
| Age | Mean (SD) | 71.77 (13.44) | 72.40 (13.59) | 71.99 (13.28) |
| Age, distribution, n (%) | <70 years | 1,148 (41.44) | 2,388 (39.01) | 29,012 (40.15) |
| ≥70 years | 1,622 (58.56) | 3,733 (60.99) | 43,240 (59.85) | |
| Gender, n (%) | Male | 1,107 (39.96) | 2,519 (41.15) | 38,777 (53.67) |
| Female | 1,663 (60.04) | 3,602 (58.85) | 33,475 (46.33) | |
| Severity of stroke, n (%) | Mild (≥45 pts) | 1,095 (39.53) | 2,799 (45.73) | 37,489 (51.89) |
| Moderate (30–44 pts) | 502 (18.12) | 981 (16.03) | 10,352 (14.33) | |
| Severe (15–29 pts) | 307 (11.08) | 605 (9.88) | 6,217 (8.60) | |
| Very severe (≤14 pts) | 380 (13.72) | 685 (11.19) | 6,825 (9.45) | |
| Unknown | 486 (17.55) | 1,051 (17.17) | 11,369 (15.74) | |
| Type of stroke, n (%) | Intracerebral hemorrhage | 313 (11.30) | 724 (11.83) | 8,067 (11.17) |
| Ischemic | 1,906 (68.81) | 4,245 (69.35) | 51,588 (71.40) | |
| Unspecified | 551 (19.89) | 1,152 (18.82) | 12,597 (17.43) | |
| Comorbidity index, n (%)* | No comorbidity, 0 | 1,108 (40.00) | 2,476 (40.45) | 37,401 (51.76) |
| Moderate comorbidity, 1 | 626 (22.60) | 1,289 (21.06) | 12,123 (16.78) | |
| Severe comorbidity, 2+ | 1,036 (37.40) | 2,356 (38.49) | 22,728 (31.46) | |
| Former stroke, n (%) | Yes | 717 (25.88) | 1,480 (24.18) | 13,772 (19.06) |
| No | 1,803 (65.09) | 4,226 (69.04) | 54,166 (74.97) | |
| Missing | 250 (9.03) | 415 (6.78) | 4,314 (5.97) | |
| Education, n (%) | Long | 49 (1.77) | 125 (2.04) | 2,015 (2.79) |
| Medium | 184 (6.64) | 422 (6.89) | 6,414 (8.88) | |
| Short | 605 (21.84) | 1,509 (24.65) | 20,596 (28.51) | |
| High school | 46 (1.66) | 71 (1.16) | 1,038 (1.44) | |
| Primary school | 1,397 (50.43) | 2,939 (48.02) | 30,368 (42.03) | |
| Missing | 489 (17.65) | 1,055 (17.24) | 11,821 (16.36) | |
| Type of antipsychotics† | Typical | 1,635 (20.80) | 6,230 (79.21) | 0.00 (0.00) |
| Atypical | 1,323 (58.80) | 927 (41.20) | 0.00 (0.00) | |
| Preadmission drug use | Antihypertensive drug, n (%) | 2,119 (76.50) | 4,871 (79.58) | 50,178 (69.45) |
| Lipid-lowering drugs, n (%) | 572 (20.65) | 1,562 (25.52) | 17,135 (23.72) | |
| Platelet inhibitors, n (%) | 1,556 (56.17) | 3,663 (59.84) | 36,547 (50.58) | |
| Antidiabetic drugs, n (%) | 389 (14.04) | 850 (13.89) | 8,274 (11.45) | |
| BMI, n (%) | <18.5 | 101 (3.65) | 219 (3.58) | 2,149 (2.97) |
| 18.5-<25 | 663 (23.94) | 1,705 (27.85) | 20,365 (28.19) | |
| ≥25 | 822 (29.68) | 1,796 (29.34) | 23,302 (32.25) | |
| Missing | 1,184 (42.74) | 2,401 (39.23) | 26,436 (36.59) | |
| Alcohol units/week, n (%) | ≤14 for women/≤ 21 for men | 1,842 (66.50) | 4,364 (71.30) | 55,108 (76.27) |
| >14 for women/> 21 for men | 208 (7.51) | 507 (8.28) | 5,068 (7.01) | |
| Missing | 720 (25.99) | 1,250 (20.42) | 12,076 (16.71) | |
| Smoking habits, n (%) | Never | 551 (19.89) | 1,528 (24.96) | 20,989 (29.05) |
| Daily or occasionally | 1,069 (38.59) | 2,183 (35.66) | 23,158 (32.05) | |
| Former (>½ year) | 356 (12.85) | 1,005 (16.42) | 14,410 (19.94) | |
| Missing | 794 (28.66) | 1,405 (22.95) | 13,695 (18.95) | |
Modified Charlson’s index (cerebrovascular disorders excluded).
Sums of proportions can exceed total number of users; some patients will appear in both categories, e.g. current use of atypical and former use of typical antipsychotics.