Elevated systemic dissemination of K. pneumoniae in GSNOR−/− mice. Bacterial titers in whole blood 48 hours after intranasal K. pneumoniae infection of wild-type (WT, open circles) and GSNOR−/− (closed diamonds) mice in three independent experiments individually (A) and aggregately (B). Each data point represents a single mouse, and horizontal lines represent the group mean. Blood bacterial titers are over 1,700 fold higher in GSNOR−/− mice (n = 13) compared to wild-type controls (n = 17, two mice without detectible titer not shown), P = 0.001.