Table 3. TRAF family gene polymorphisms in autoimmune diseases.
Gene | SNP | Autoimmune | Race | P value | OR (95%CI) |
Disease | |||||
TRAF1 [51], [52], [53] | rs3761847 | SLE | Japanese | 0.016 | 1.36 (1.05–1.76) |
RA | North American | 4×10−14 | 1.30 (1.23–1.42) | ||
& Swedish | |||||
RA | Japanese | 0.031 | 1.18 (1.01–1.39) | ||
rs7021206 | RA | Korean | 0.0037 | 1.21 (1.06–1.38) | |
TRAF6 [54] | rs5030445 | SLE | African American | 0.00173 | 0.68 (0.53–0.87) |
rs5030437 | SLE | African American | 0.004456 | 0.70 (0.54–0.90) | |
rs5030472 | SLE | European | 0.003342 | 0.65 (0.49–0.87) | |
rs5030470 | SLE | European | 0.000179 | 0.55 (0.40–0.76) | |
TRAF3IP2 [23], [24], [55], [56] | rs33980500 | psoriasis | German | 1.24×10−16 | * |
PsA | German | 4.57×10−12 | 1.95 | ||
SLE | Italian | 0.021 | 1.71 | ||
rs13210247 | psoriasis | German | 2..36×10−10 | * | |
PsA | German | 5.76×10−7 | 2.08 (1.61–2.69) | ||
BD | Chinese | 7.05×10−8 | 2.63 (1.87–3.68) | ||
VKH | Chinese | 3.31×10−5 | 2.18 (1.56–3.05) | ||
rs13190932 | PsA | German | 9.19×10−7 | 2.19 (1.66–2.88) | |
UC | Italian | 0.02 | 5.05 (1.12–2.83) | ||
CD | Italian | 0.026 | 3.03 (1.1–8.3) | ||
rs13196377 | PsA | German | 9.36×10−7 | 2.17 (1.66–2.88) | |
SLE | Italian | 0.002 | 2.59 (1.39–4.80) | ||
UC | Italian | 0.049 | 4.1 (0.91–18.18) | ||
TRAF5 [18] | rs10863888 | RA | UK Caucasian | 0.003 | 1.39 (1.11–1.75) |
BD | Chinese | 0.009 | 1.34 (1.13–1.60) | ||
rs7514863 | RA | UK Caucasian | 0.005 | 1.2 (1.06–1.36) |
The data not stated in paper.
SLE, Systemic Lupus Erythematosus; RA, Rheumatoid Arthritis; PsA, Psoriatic Arthritis; UC, Ulcerative Colitis; CD, Crohn's Disease.