Table 3. Differentially abundant plasma and urine peptides (900–3000 m/z) correlating with cervical cancer, CIN 2 or control samples.
No. | Peptide Mass (m/z) | Sample Set | Protein Identified | Distribution in Samples |
1 | 904.53 | FX3a | kininogen L,high MW | Absent in Control; Cerv Ca = CIN 2 |
2 | 1097.49 | Urine | – | CIN 2 = Control>Cerv Ca |
3 | 1126.503 | Urine | alpha-1 type I collagen | CIN 2> Cerv Ca >Control |
4 | 1192.67 | FX3a | – | Absent in Control; Cerv Ca = CIN 2 |
5 | 1236.56 | Urine | alpha-1 type I collagen | CIN 2> Control>Cerv Ca |
6 | 1425.65 | Urine | alpha-1 type XVII collagen | Absent in Control; CIN 2>Cerv Ca |
7 | 1524.71 | Urine | – | CIN 2> Cerv Ca = Control |
8 | 1530.91 | FX1b | – | Absent in CIN 2; Cerv Ca = Control |
9 | 1587.97 | Urine | – | CIN 2> Control>Cerv Ca |
10 | 1746.78 | FX1b, FX2c | – | Control>Cerv Ca = CIN 2 |
11 | 1943.93 | FX2c | kininogen L,high MW | Control |
12 | 2080.98 | FX2c | kininogen L,high MW | Control |
13 | 2209.06 | FX2c | kininogen L,high MW | Control>Cerv Ca = CIN 2 |
14 | 2228.05 | FX2c | – | Absent in CIN 2; Control>Cerv Ca |
15 | 2271.13 | FX2c | – | Control>Cerv Ca = CIN 2 |
a FX3, Fraction 3: peptides released during the immunodepletion of albumin and IgG from plasma.
b FX1, Fraction 1: freely soluble plasma peptides.
c FX2, Fraction 2: peptides bound to total plasma proteins.