Skip to main content
. Author manuscript; available in PMC: 2014 Jan 8.
Published in final edited form as: Nat Cell Biol. 2013 May 19;15(7):741–750. doi: 10.1038/ncb2757

Fig.8. A working model of VPS34 complex regulation by ULK upon amino acid withdrawal.

Fig.8

Amino acid starvation inactivates TORC1, de-repressing ULK1. ULK1 is recruited to VPS34-Beclin-1 complexes via binding to ATG14L, phosphorylating Beclin-1, activating the VPS34 kinase and PI3P production at the nascent autophagosome. Additionally, UVRAG-bound Beclin-1 is phosphorylated by ULK1, which may promote autophagosome maturation.