. 2013 Sep 12;12(20):3272–3285. doi: 10.4161/cc.26385

Table 2. Functional roles for intracellular focal adhesion proteins in mouse development.

Gene	Knockout mouse phenotype
α-Actinin-4	-Die at several months of age due to glomerular disease and proteinuria⁹¹
FAK	-Embryonic lethal E8.5⁴⁸^,⁴⁹ -Defect in mesodermal development⁴⁸^,⁴⁹ -Able to implant and initiate gastrulation⁴⁸^,⁴⁹
FLNA (Filamin A)	-Embryonic lethal E13.5–14.5⁹³ -Cardiac and vascular failure, and impaired brain development⁹³
ILK	-Die shortly after implantation, E8.5⁷¹^,⁷² -Fail to form epiblast⁷¹^,⁷² -Mice with kinase-dead ILK mutants (S343A) or kinase hyperactive ILK mutants (S343D) have no developmental or skin defects⁷¹^,⁷² -Mice with mutation in ATP-binding site of kinase domain (K220A or K220M) die shortly after birth due to kidney defects, but have normal skin⁷¹^,⁷²
KIND-1 (Kindlin-1)	-Skin atrophy⁸⁴ -Intestinal dysfunction resulting in perinatal lethality⁸⁴
KIND-2 (Kindlin-2)	-Peri-implantation lethality at E7⁸³ -Detachment of endoderm and epiblast from basement membrane⁸³
Migfilin	-Viable, fertile and no apparent abnormalities⁹⁵
Cas (p130Cas)	Embryonic lethality at E11.5–12.5⁹⁶ -Poor development of heart and blood vessel dilation⁹⁶
Paxillin	-Embryonic lethality at E9.5⁹⁹ -Disrupted development of mesodermal structures⁹⁹
PINCH1	-Embryonic lethality at E6.5 or E9.5¹⁰⁰^,¹⁰¹ -Disorganized egg cylinder, and significant cell death¹⁰⁰^,¹⁰¹ -Abnormal epiblast polarity, and impaired cavitation into basement membrane¹⁰⁰^,¹⁰¹
PINCH2	-Viable, fertile with no apparent phenotype¹⁰²
Talin	-Embryonic lethality at E8.5–9.5¹⁴⁵ -Disorganization of embryos at gastrulation¹⁴⁵ -Defective embryonic ectoderm¹⁴⁵
Tensin	-Normal at birth, but develop kidney abnormalities that lead to lethality¹⁰⁶
Tensin-3	-Growth retardation and postnatal lethality in 1/3 of mice that is associated with impaired development of the intestine, lung and bone¹⁰⁷
Vinculin	-Embryonic lethality around E8–10¹⁴⁶ -Attenuated cranial nerve, spinal nerve and heart development¹⁴⁶ -Defective ectoderm development¹⁴⁶
Zyxin	-Viable, fertile and no apparent abnormalities¹¹⁰