Table 3. Functional roles for intracellular focal adhesion proteins in mouse skin.

Gene	Conditional skin knockout phenotype (K5 or K14 promoter)	Role in SCC
FAK	-Hair cycle irregularities52 -Loss of proliferation in sebaceous gland52 -Slight epidermal thinning, but no change in wound healing52	-FAK+/− mice show reduced papilloma formation, but no change in conversion of papillomas to SCCs upon DMBA-TPA treatment54 -K14-CreER 4-OHT induced deletion of FAK in the epidermis both prevented tumor formation and stopped tumor progression upon DMBA-TPA treatment55
ILK	-Epidermal blistering73 -Movement of proliferative cells to suprabasal layers73 -Hair loss73	N/A