Figure 1. Mice with conditional inactivation of Tp53 initiating in HSCs or DN thymocytes reproducibly succumb to thymic lymphomas. (A) Kaplan–Meier curves comparing tumor-free survival of 22 VP and 20LP mice. All tumors were thymic lymphomas other than 2 VP mice that succumbed to B lineage lymphomas (indicated by asterisks). Additionally, one LP mouse succumbed to a sarcoma, and one mouse of each cohort did not succumb to any tumors by 1 year of age. Curves were compared using the log-rank (Mantel–Cox) test, P = 0.134 (B) Flow cytometry analyses of VP lymphomas no 118 and 975 and of LP lymphomas no. 740 and 976 showing their surface expression of CD3 and TCRβ or CD4 and CD8. Gates were drawn on normal T cells analyzed in parallel with the lymphomas. The percentages of cells in each gate are indicated. (C) Flow cytometry analyses of VP lymphomas no. 421 and 426 showing their surface expression of B220 and IgM or Igκ and Igλ. Gates were drawn on normal B cells analyzed in parallel with lymphomas. The percentages of tumor cells in each gate are indicated.