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. 2013 Sep 9;12(20):3307–3316. doi: 10.4161/cc.26299

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Copyright © 2013 Landes Bioscience

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graphic file with name cc-12-3307-g4.jpg — Figure 4. Mice with conditional inactivation of Tp53 initiating in HSCs or DN thymocytes develop lymphomas with oncogenic antigen receptor locus translocations. (A) Cytogenetic analysis of a metaphase from VP lymphoma no. 820 with the clonal t(2;17) translocation circled or isolated. (A, i) Spectral image. (A, ii) DAPI image. (A, iii) Karyotype table. (B) Cytogenetic analyses of a metaphase or chromosome from VP lymphoma no. 421 with the clonal t(12;15) translocation circled. (B, i) SKY image. (B, ii) DAPI image. (B, iii) Karyotype table. (B, iv). SKY (left) or FISH image (right) of the t(12;15) translocation hybridized with 3′IgH (green) and c-Myc (red) probes. (C) Cytogenetic analyses of a metaphase or chromosome from LP lymphoma no. 902 with the clonal t(4;15;14) translocation circled or isolated. (B, i) SKY image. (B, ii) DAPI image. (B, iii) Karyotype table. (B, iv) SKY (top) or FISH images of the t(4;15;14) translocation. (middle) hybridized with TCRVδ3/Vα6 (green) and TCRCα (red) probes. (bottom) hybridized with c-Myc (green) probe.