Table 2. Susceptibility of GP to B. anthracis strains in the SC injection model.
Strain | Description | Inoculum (CFU) | Dead/infected | MTTD (days) |
Vollum | pXO1+pXO2+ | 103 | 6/6 | 3 |
Vollum ΔpXO1ΔpXO2 | pXO1−pXO2− | 108 | 0/8 | >14 |
Vollum ΔpXO1 | pXO1−pXO2+ | 108 | 0/5 | >14 |
Vollum ΔpagΔcyaΔlef | Complete deletion of the pag, lef and cya genes | 106 | 2/3 | 2.5 |
105 | 4/6 | 5.75 | ||
Vollum ΔpagΔcyaΔlefΔatxA | Complete deletion of the pag, lef, cya and atxA genes | 108 | 0/4 | >14 |
107 | 0/4 | |||
Vollum ΔpXO2ΔpagΔcyaΔlef | Complete deletion of pXO2 and the pag, lef and cya genes | 108 | 0/4 | >14 |
Vollum ΔpXO2 | pXO1+pXO2− | 108 | 4/5 | 7.75 |
107 | 0/5 | >14 |