Table 4. Clinical characteristics of total study population, and comparison of clinical variables: Adenovirus (Ad) vs. 2009 H1N1, and coinfection vs. Ad alone.

	Total study population (n = 375)	Ad +(n = 255)	2009 H1N1 +(n = 58)	p-value	Ad+/2009 H1N1+(n  = 16)α	p-value
Symptoms
Subjective fever	373 (99.5%)	253 (99.2%)	58 (100%)	1.0	16 (100%)	1.0
Cough	336 (89.6%)	226 (88.6%)	56 (96.6%)	0.01	15 (93.8%)	1.0
Sore throat	326 (86.9%)	236 (92.5%)	43 (74.1%)	<0.01	11 (68.8%)	<0.01
Sinus congestion	301 (80.3%)	206 (80.8%)	44 (75.9%)	0.34	13 (81.3%)	0.26
Myalgia	295 (78.7%)	196 (76.9%)	47 (81.0%)	0.49	15 (93.8%)	0.21
Coryza	241 (64.3%)	155 (60.8%)	45 (77.6%)	0.02	12 (75.0%)	0.12
Malaise	198 (52.8%)	132 (51.8%)	35 (60.3%)	0.25	8 (50.0%)	0.88
Vomiting	45 (12.0%)	32 (12.5%)	6 (10.3%)	0.64	3 (18.8%)	0.44
Diarrhea	21 (5.6%)	20 (7.8%)	0	0.03	0	0.62
Duration of symptoms (days; IQR*)	3 (2–4)	3 (2–5)	2 (2–3)	<0.01	2.5 (2–3)	0.09
Vital Signs**
Heart Rate	94.1 (14.1)	93 (15)	97 (12)	0.08	95 (10)	0.71
Respiratory Rate	17.0 (1.8)	17 (2)	17 (1)	0.92	17 (2)	0.37
Systolic BP***	119.6 (9.3)	120 (9)	119 (11)	0.67	120 (11)	0.92
Diastolic BP***	71.9 (7.5)	72 (7)	71 (9)	0.13	71 (3)	0.61
Oral temperature (0F)	101.5 (0.9)	101.5 (0.8)	101.7 (1.0)	0.07	101.9 (0.9)	0.03
Physical exam
Pharyngitis	283 (75.5%)	203 (79.6%)	38 (65.5%)	<0.01	9 (56.2%)	<0.01
Exudativepharyngitis	22 (5.9%)	21 (8.2%)	1 (1.7%)	0.045	0	0.24
Lymphadenopathy	189 (50.4%)	131 (51.4%)	32 (55.2%)	0.78	5 (31.3%)	0.08
Tonsillitis	64 (17.1%)	53 (20.8%)	2 (3.4%)	<0.01	0	0.02
Abnormal lung exam	11 (2.9%)	7 (2.7%)	2 (3.4%)	0.30	0	0.63
Pneumonia	6 (1.6%)	4 (1.6%)	1 (1.7%)	1.00	0	0.78
Hospitalized	3 (0.8%)	2 (0.8%)	0	1.00	0	1.00

median, interquartile range.

mean, standard deviation.

BP  =  blood pressure (mmHg).

compared to Ad alone.