Table 1. Association of MT staining and clinicopatological factors. Tumor type not taken into account.
Factor | Number of studies | Number of participants | OR/HR* (95% CI) | Heterogeneity | Publication bias | Model | |
P-value | I2 (%) | P-value | |||||
Age | 9 | 1069 | 1.07 (0.82–1.39) | 0.679 | 0.00 | 0.117 | Fixed effects |
Gender | 9 | 944 | 0.99 (0.74–1.34) | 0.393 | 5.08 | 0.611 | Fixed effects |
Tumor vs. control | 31 | 2454 | 1.19 (0.47–3.01) | 0.000 | 89.58 | 0.236 | Random effects |
Tumor stage | 19 | 1237 | 1.15 (0.74–1.77) | 0.000 | 60.83 | 0.987 | Random effects |
Tumor size | 6 | 1962 | 1.37 (0.45–4.13) | 0.000 | 90.88 | 0.194 | Random effects |
Tumor grade | 33 | 2504 | 1.58 (1.08–2.30) | 0.000 | 66.57 | 0.886 | Random effects |
Metastases, nodal + distant | 21 | 1987 | 1.59 (1.03–2.46) | 0.000 | 71.68 | 0.039 | Random effects |
Metastases, distant | 6 | 741 | 1.56 (0.56–4.37) | 0.014 | 64.82 | 0.075 | Random effects |
Metastases, nodal | 15 | 1246 | 1.62 (0.98–2.68) | 0.000 | 72.92 | 0.201 | Random effects |
Overall survival | 10 | 2041 | 2.04 (1.47–2.81) | 0.000 | 97.69 | 0.572 | Random effects |
Heterogeneity of studies analyzed using Cochran's Q-test (p-value displayed) and using I2. Egger's two-tailed test used for publication bias analysis (p-value displayed). * effect measure is odds ratio, OR, except for survival analysis using hazard ratio, HR. CI, confidence interval