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. 2014 Jan 8;9(1):e85346. doi: 10.1371/journal.pone.0085346

Table 2. Association of MT staining and clinicopathological factors – individual tumor types taken into account.

Tumor Factor Number of studies OR/HR* (95% CI) Heterogeneity Model
P-value I2 (%)
bladder Tumor vs. control 2 1.68 (0–1135.79) 0.002 89.89 Random effects
Tumor stage 3 1.56 (0.77–3.16) 0.354 3.64 Fixed effects
Tumor grade 3 0.96 (0.21–4.33) 0.027 72.24 Random effects
Metastases, nodal + distant 3 1.78 (0.57–5.51) 0.070 62.44 Random effects
Metastases, nodal 2 1.96 (0.40–9.66) 0.022 80.89 Random effects
Metastases, distant 1 1.31 (0.21–8.27) - - -
Overall survival 1 2.06 (1.26–3.37) - - -
breast Tumor vs. control 1 0.07 (0.00–1.29) - - -
Tumor stage 1 1.20 (0.59–2.43) - - -
Tumor size 1 1.73 (0.68–4.40) - - -
Tumor grade 5 1.85 (1.22–2.82) 0.096 49.19 Fixed effects
Metastases, nodal + distant 3 2.57 (0.59–11.26) 0.001 86.55 Random effects
Metastases, nodal 3 2.57 (0.59–11.26) 0.001 86.55 Random effects
colorectal Tumor vs. control 1 0.02 (0.00–0.24) - - -
Tumor stage 5 1.27 (0.51–3.16) 0.000 83.09 Random effects
Tumor size 2 0.71 (0.32–1.56) 0.299 7.15 Fixed effects
Tumor grade 6 2.32 (0.86–6.29) 0.000 77.64 Random effects
Metastases, nodal + distant 6 1.11 (0.38–3.24) 0.001 75.84 Random effects
Metastases, nodal 4 1.12 (0.30–4.16) 0.001 82.13 Random effects
Metastases, distant 2 1.04 (0.07–15.17) 0.050 73.87 Random effects
Overall survival 1 1.05 (1.00–1.10) - - -
esophageal Metastases, nodal + distant 2 2.89 (1.17–7.15) 0.464 0.00 Fixed effects
Metastases, nodal 1 2.30 (0.77–6.85) Fixed effects
Metastases, distant 1 4.78 (0.94–24.33) - - -
gallbladder Tumor vs. control 1 34.41 (1.76–673.37) - - -
Tumor grade 1 2.25 (0.37–13.71) - - -
hepatocellular Tumor vs. control 3 0.10 (0.03–0.30) 0.548 0.00 Fixed effects
Tumor stage 1 3.53 (0.36–34.18) -
Tumor size 2 1.04 (0.12–9.42) 0.023 80.53 Random effects
Tumor grade 2 0.47 (0.28–0.80) 0.832 0.00 Fixed effects
Metastases, nodal + distant 1 0.62 (0.39–0.98) - - -
Metastases, distant 1 0.62 (0.39–0.98) - - -
head and neck Tumor vs. control 5 9.95 (5.82–17.03) 0.191 34.56 Fixed effects
Tumor stage 2 2.02 (0.36–11.27) 0.123 58.04 Random effects
Tumor grade 4 0.72 (0.22–2.40) 0.091 53.68 Random effects
Metastases, nodal + distant 2 3.49 (0.25–48.04) 0.036 77.24 Random effects
Metastases, nodal 2 3.49 (0.25–48.04) 0.036 77.24 Random effects
Overall survival 2 3.14 (1.61–6.15) 0.826 0.00 Fixed effects
kidney Tumor vs. control 2 0.06 (0.00–2.20) 0.043 75.47 Random effects
Tumor stage 2 0.38 (0.07–2.13) 0.086 66.00 Random effects
Tumor grade 2 1.74 (0.66–4.59) 0.001 90.91 Fixed effects
lung Tumor grade 1 0.92 (0.05–18.12) - - -
Overall survival 2 1.03 (0.63–1.67) 0.622 0.00 Fixed effects
lung, adenoca. Tumor grade 1 5.77 (0.29–116.67) - - -
lung, squamous cell Tumor grade 1 0.15 (0.01–2.81) - - -
melanoma Tumor vs. control 2 9.41 (0.03–3106.54) 0.000 93.39 Random effects
Tumor size 1 4.85 (3.51–6.70) - - -
Metastases, nodal + distant 2 2.47 (1.30–4.70) 0.336 0.00 Fixed effects
Metastases, nodal 1 2.23 (1.14–4.39) - - -
Metastases, distant 1 6.63 (0.81–54.61) - - -
Overall survival 1 7.16 (4.71–10.89) - - -
ovary Tumor vs. control 4 7.83 (1.09–56.29) 0.003 78.82 Random effects
Tumor grade 2 3.08 (1.38–6.88) 0.616 0.00 Fixed effects
Overall survival 1 1.58 (1.01–2.47) - - -
prostate Tumor vs. control 2 0.74 (0–4095.48) 0.000 95.32 Random effects
Tumor grade 4 2.09 (0.86–5.07) 0.365 5.64 Fixed effects
Gleason Grade 2 1.40 (0.47–4.14) 0.238 28.06 Fixed effects
Overall survival 1 1.86 (1.79–1.94) - - -
stomach Tumor vs. control 3 3.50 (0.17–73.01) 0.000 95.71 Random effects
Tumor stage 1 0.73 (0.33-1.63) - - -
Tumor grade 1 1.45 (0.67–3.14) - - -
Metastases, nodal + distant 1 0.59 (0.27–1.28) - - -
Metastases, nodal 1 0.59 (0.27–1.28) - - -
Overall survival 1 4.23 (1.8–9.94) - - -
testes Tumor stage 2 0.33 (0.10–1.03) 0.301 6.54 Fixed effects
thyroid Tumor vs. control 3 0.39 (0.16–0.95) 0.182 41.39 Fixed effects
thyroid, follicular Tumor vs. control 3 2.27 (1.11–4.63) 0.212 35.59 Fixed effects
thyroid, medullar Tumor vs. control 1 0.11 (0.03–0.39) - - -
thyroid, papillary Tumor vs. control 3 0.23 (0.02–2.85) 0.026 72.64 Random effects
uterine Tumor vs. control 1 0.01 (0.00–0.10) - - -
Tumor stage 2 1.53 (0.61–3.86) 0.538 0.00 Fixed effects
Tumor grade 2 2.81 (1.17–6.8) 0.569 0.00 Fixed effects
Metastases, nodal + distant 1 1.01 (0.27–3.79) - - -
Metastases, nodal 1 1.01 (0.27–3.79) - - -

Heterogeneity of studies analyzed using Cochran's Q-test (p-value displayed) and using I2. Egger's two-tailed test used for publication bias analysis (p-value displayed). * effect measure is odds ratio, OR, except for survival analysis using hazard ratio, HR. No heterogeneity test and no model indicated when 1 study per factor analyzed. CI, confidence interval.