Fig. 4.

Morphology of N-TIRE-induced lesions in the subcortical white matter of Dog 4. (A) Partial obliteration and vacuolization of the white matter in the corona radiata (luxol fast blue and Periodic Acid Schiff counterstain) with loss of the gray and white matter junctional distinction (inset, control). (B) Disruption of the axonal projections of the corona radiata (inset, control) of Dog 2 (Bielschowsky silver stain). (C) Vacuolar change in the white matter with axonal spheroids (arrows) in Dog 3 (H&E). LV: lateral ventricle. Scale bars = 200 µm (C), 5.0 mm (A, A inset, B and B inset).