Fig. 5.

Morphology of N-TIRE-induced lesions in the deep cortical gray matter. (A) N-TIRE ablated regions (left side of panel) were sharply demarcated from the adjacent normal brain (right side) identified by their pallor. A focus of intraparenchymal hemorrhage associated with a disrupted capillary bed was visible at the lesion periphery (arrow) in Dog 2. (B) Necrotic neurons (arrowheads) and degenerate free glial nuclei in the N-TIRE-associated lesion core in Dog 4. (C) Gitter cells and intact vessels (arrows) were present in the transition zone between the affected and normal brain tissue in Dog 3. H&E. Scale bars = 200 µm (B and C inset), 500 µm (C), 2.0 mm (A).