Fig. 1.

Symptom severity score, body weight and anxiety-related behaviour of Mecp2^Stop mice. Means ± SEM. (A) Mecp2^Stop mice presented with a progressively increasing symptom score, which attained a mean of 5/6 in weeks 16–24 of testing. (B) Mecp2^Stop mice also displayed a sustained increase in body weight compared to WT's. Shaded area indicates period of behavioural assessment. (C) Ambulatory activity in the open field during 10 min of recording plotted in minute bins. Mecp2^Stop mice presented with reduced locomotor activity. No reliable habituation occurred in either WT or Mecp2^Stop mice. Fear-signalling visits to the centre of the open field (D) or open arms of the elevated plus maze (E) was not affected by transgene knockout. *p < 0.05.