Table 3.
Top scoring 7 representative gene candidates from stringent overlap in siRNA duplex screens
| Coverage | Gene | Name | Overlap1 | Biological process |
|---|---|---|---|---|
| GW | N/A | N/A | N/A | N/A |
|
| ||||
| FD | PLK1 | Polo-like kinase 1 | 6/8 | Cell cycle regulator important for M phase progression |
| PRKCL1 | Protein kinase N1 | 3/8 | Signal transduction (apoptosis mediated) | |
| DUT | Deoxyuridine triphosphatase | 2/8 | Essential enzyme of nucleotide metabolism | |
| NME3 | Nucleoside diphosphate kinase 3 | 2/8 | Nucleoside biosynthesis, apoptosis induction | |
| PPP1R12C | Protein phosphatase 1, regulatory subunit 12C | 2/8 | Regulates assembly of actin cytoskeleton | |
|
| ||||
| GW & FD | AURKB | Aurora kinase B | 2/9 | Role in chromosome segregation |
| PSMA4 | Proteasome subunit, α type, 4 | 2/9 | Ubiquitin-dependent peptide cleavage | |
1
Number of gene lists with nominated gene/total number of gene lists in that category, N/A; Not applicable as only 1 gene lists remain in this category, GW; genome-wide, FD; focused.