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. 2014 Jan 9;7:194. doi: 10.3389/fncom.2013.00194

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Copyright © 2014 Gershman, Moustafa and Ludvig.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of methamphetamine on timing in (A) the peak procedure and (B) the bisection procedure in rats. Each curve in (A) represents response rate as a function of time, where time 0 corresponds to the trial onset. The methamphetamine curve corresponds to sessions in which rats were injected with methamphetamine; the baseline curve corresponds to sessions in which rats did not receive an injection. Each curve in (B) represents the proportion of trials on which the rat chose the “long” option as a function of probe cue duration. The saline curve corresponds to sessions in which the rat received a saline injection. In both procedures, methamphetamine leads to overestimation of the elapsing interval, producing early responding in the peak procedure and more “long” responses in the bisection procedure. Figure replotted from Maricq et al. (1981).