Table 4.

Effects of chronic sertraline and sex on behavior during the social interaction test.

Social interaction test	Male 0 mg/kg	Male 5 mg/kg	Male 10 mg/kg	Male 20 mg/kg	Female 0 mg/kg	Female 5 mg/kg	Female 10 mg/kg	Female 20 mg/kg
ACCLIMATION AND INTERACTION
Time in interaction zone (empty)	71.0 ± 11.9	85.5 ± 13.1	95.3 ± 9.9	78.5 ± 9.6	50.9 ± 14.1	80.3 ± 16.7	103.9 ± 14.3	74.9 ± 16.9
Time in interaction zone (target)	119.1 ± 21.0	102.3 ± 24.2	106.9 ± 13.6	88.7 ± 8.9	53.0 ± 15.0†	116.1 ± 13.7**	92.0 ± 23.8	40.0 ± 19.0
Time in corners zone (empty)	12.2 ± 5.3	5.3 ± 2.3	4.1 ± 1.6	16.4 ± 6.9	38.8 ± 18.6	6.6 ± 1.5	5.2 ± 2.0	16.5 ± 10.6
Time in corners zone (target)	18.4 ± 12.8	32.6 ± 27.7	1.6 ± 0.5	13.0 ± 6.8	57.6 ± 31.5	4.1 ± 2.4	12.9 ± 5.5	76.7 ± 32.8
Total distance (empty)	26.5 ± 3.9	17.7 ± 4.6	31.2 ± 8.2	21.6 ± 2.4	29.6 ± 7.1	46.7 ± 6.7	18.1 ± 2.4	19.5 ± 4.9
Total distance (target)	26.2 ± 3.4	19.5 ± 3.3	30.5 ± 5.8	15.9 ± 6.7	41.6 ± 9.0	24.0 ± 6.0	24.0 ± 6.0	30.1 ± 6.9
OPEN FIELD
Time in center zone	20.1 ± 4.1	20.6 ± 3.6	36.9 ± 11.9*	17.3 ± 2.0	20.4 ± 5.2	26.9 ± 4.2	28.4 ± 4.6*	17.1 ± 5.5
Time in sides zone	111.4 ± 13.0	120.1 ± 18.6	72.8 ± 21.5	119.1 ± 32.5	119.7 ± 12.1	108.1 ± 16.7	111.7 ± 13.8	135.8 ± 17.2
Total distance	17.8 ± 5.6	15.6 ± 4.9	21 ± 7.2	22.1 ± 6.2	21.0 ± 7.7	24.3 ± 5.9	16.5 ± 3.8	12.2 ± 5.3

Data shown as mean ± SE.

Times in sec, distances in m.

^†p < 0.05, sex difference.

^*p < 0.05,

^**p < 0.01, trt difference.