Table 5.
Effects of chronic sertraline and sex on behavior during tests of antidepressant function.
Tests | Male 0 mg/kg | Male 5 mg/kg | Male 10 mg/kg | Male 20 mg/kg | Female 0 mg/kg | Female 5 mg/kg | Female 10 mg/kg | Female 20 mg/kg |
---|---|---|---|---|---|---|---|---|
SUCROSE ANHEDONIA | ||||||||
Day 1 %sucrose consumption | 63.6 ± 4.3 | 63.9 ± 3.3 | 67.7 ± 9.4 | 60.5 ± 6.8 | 50.3 ± 4.9 | 68.2 ± 4.0 | 65.9 ± 2.2 | 65.7 ± 3.1 |
Day 2 %sucrose consumption | 73.0 ± 3.8 | 66.8 ± 5.1 | 65.0 ± 4.4 | 70.7 ± 3.0 | 63.5 ± 5.6 | 71.5 ± 4.5 | 71.1 ± 3.5 | 69.1 ± 3.4 |
Average %sucrose consumption | 68.3 ± 3.4 | 65.4 ± 3.2 | 66.3 ± 5.4 | 65.6 ± 4.7 | 56.9 ± 4.4 | 69.9 ± 3.5 | 68.5 ± 2.4 | 67.4 ± 3.0 |
FORCED SWIM TEST | ||||||||
Immobility time | 30.3 ± 20.7 | 27.2 ± 17.1 | 15.0 ± 7.9 | 79.5 ± 71.4 | 72.0 ± 38.6 | 37.8 ± 12.6 | 16.0 ± 8.7 | 35.6 ± 15.4 |
Data are shown as mean ± SE.
All times in sec.
% sucrose = sucrose/(sucrose + water) *100.