Table 7.

Effects of acute sertraline on male and female behavior.

Social interaction test	Male 0 mg/kg	Male 5 mg/kg	Female 0 mg/kg	Female 5 mg/kg
ACCLIMATION AND INTERACTION
Time in interaction zone (empty)	78.1 ± 15.5	84.6 ± 9.8	76.2 ± 9.4	55.4 ± 14.4
Time in interaction zone (target)	54.0 ± 22.5	44.7 ± 20.7	50.2 ± 23.8	55.0 ± 19.6
Time in corners zone (empty)	5.3 ± 2.0	6.0 ± 1.9	10.1 ± 2.3	12.2 ± 5.4
Time in corners zone (target)	3.7 ± 1.7	4.3 ± 1.3	24.1 ± 10.2	37.8 ± 28.3
Total distance (empty)	22.4 ± 6.3	17.8 ± 2.7	18.6 ± 1.6	25.3 ± 5.2
Total distance (target)	18.0 ± 6.5	13.0 ± 3.2	20.1 ± 6.1	19.7 ± 5.1
OPEN FIELD
Time in center zone	40.3 ± 7.3	44.3 ± 7.7	28.8 ± 4.2	46.2 ± 12.7
Time in sides zone	66.4 ± 9.8	72.1 ± 9.4	92.4 ± 12.0	73.1 ± 11.2
Total distance	28.8 ± 2.3†	25.2 ± 1.3	20.3 ± 2.2	20.3 ± 3.1
FORCED SWIMMING
Immobility time	14.5 ± 5.0	53.5 ± 17.5*	10.3 ± 2.8	24.7 ± 11.5*

Data are shown as mean ± SE.

All times in sec, all distances in m.

^†p < 0.05, sex difference.

^*p < 0.05, dose effect.

n = 4–6 per group.