Table 3. Postoperative Outcomes and Hematologic Data.
| Patients | Low-Dose Fentanyl Plus Placebo | Low-Dose Fentanyl Plus Dexmedetomidine | High-Dose Fentanyl Plus Placebo | p |
|---|---|---|---|---|
| Length of CTICU stay (d) | 1 (1–4) | 2 (1–5) | 1 (1–8) | 0.5995 |
| Length of hospital stay (d) | 5 (3–15) | 5 (3–23) | 5.5 (3–32) | 0.5561 |
| Time on ventilator (hr) | 3.79 (0–16) | 2.4 (0–2.4) | 10.75 (0–27.32) | 0.43 |
| Inotropic score on CTICU admission | 2.5 (0–2.5) | 2.5 (0–5) | 2.5 (0–5) | 0.2541 |
| Inotropic score on postoperative day 1 | 2.5 (0–2.5) | 2.5 (0–7.5) | 2.5 (0–5) | 0.1728 |
| Bloodless throughout hospitalization (n, %) | 0 (0) | 0 (0) | 4 (23.5) | 0.0286 |
| Preoperative platelet count (K/cu mm) | 345 (216–511) | 357 (187–521) | 326 (201–696) | 0.9681 |
| Postoperative platelet count (K/cu mm) | 106 (48–250) | 116 (48–250) | 132 (75–287) | 0.5500 |
| Postoperative prothrombin time (s) | 20 (17.5–24.7) | 19.2 (15.9–24.7) | 18.8 (15.9–21.5)* | 0.0466 |
| Postoperative partial thromboplastin time (s) | 42.5 (32–86) | 44 (30–250) | 40 (28–61) | 0.3365 |
| Postoperative international normalized ratio | 1.7 (1.5–2.3) | 1.6 (1.3–2.3) | 1.6 (1.3–1.9)* | 0.1018 |
| Postoperative fibrinogen (mg/dL) | 118 (68–165) | 135 (68–222) | 143 (93–222)# | 0.1882 |
| Postoperative absolute neutrophil count (cells/cu mm) | 7,260 (3,100–16,184) | 8,643 (4,514–13,272) | 9,380 (3,690–16,960)# | 0.1343 |
CTICU = cardiothoracic ICU.
p ≤ 0.03 versus low-dose fentanyl plus placebo.
p = 0.07 versus low-dose fentanyl plus placebo.
Data represent median (range) unless otherwise specified.