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. Author manuscript; available in PMC: 2014 Jan 9.
Published in final edited form as: Chem Biol. 2013 Mar 21;20(3):10.1016/j.chembiol.2013.01.013. doi: 10.1016/j.chembiol.2013.01.013

Figure 6.

Figure 6

Binding isotherms for A48 (the labeled analogue of 3) and the five other highest affinity members of the library in which the stereochemistry at each alpha-carbon of 3 was altered. A) General structure of the tested compounds and the KD determined by FP assay after re-synthesis as shown in B. The KD values are given in μM. B) Fluorescent polarization assay of a titration of fluorescein-labeled compound with PX4-4 C) Titration of fluorescein-labeled compound with a collection of human IgG antibodies (C). Note the different scales of the y-axes in B and C. The binding of the peptoid A41 to PX4-4 and whole human IgG is similar.