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. 2014 Jan 9;4:514. doi: 10.3389/fimmu.2013.00514

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Copyright © 2014 Yoshihara, Masaki, Matsuo, Chen, Tian and Yodoi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trx/Txnip signaling complex as redoxisome. Txnip contains an intramolecular disulfide band between Cys-63 and -247 that allows efficient interaction with Trx. Txnip forms disulfide bond with reduced TRX by disulfide exchange, making a stable Trx mixed disulfide.