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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: J Pediatr Surg. 2013 Jun;48(6):10.1016/j.jpedsurg.2013.03.042. doi: 10.1016/j.jpedsurg.2013.03.042

Fig. 3.

Fig. 3

Disrupting intestinal epithelial insulin-like growth factor-1 receptor (IGF1R) expression prevents intestinal mucosal hyperplasia in Rb-deficient mice. Villus height (A), crypt depth (B), and rates of enterocyte proliferation (C; % crypt cells staining for BrdU) were recorded in (WT; n = 8), intestinal epithelial Rb-knockout (Rb-IKO; n = 4), and IGF1R/Rb-IKO double-knockout (IGF1R/Rb-IKO; n = 7) mice (*p ≤ 0.05, **p ≤ 0.001, Student’s t-test).