Figure 2.

Pedigrees of the French families the proband of which was found to carry exon 11 UNC5C variant A628K (families 1-3), R603C (family 4) or T617I (family 5). A black filled-in circle or square shows that the individual developed a colorectal cancer, whereas a grey filled-in symbol indicates that the individual presented a cancer encompassed by the Lynch syndrome tumor spectrum. The type of cancer is precised below the affected individuals; the age at diagnosis is noted by figures next to the cancer type. Other figures below symbols indicate either the current age or the age of death of the individual. The variants carried by the individuals are noted below their respective symbols. The absence of any genotype means that no DNA sample was available for testing. CRC: Colorectal cancer; WT: Wild-type genotype.